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STRUCTURE-BASED DESIGN OF PEPTIDE INHIBITORS OF AMYLOID FIBRILLATION
STRUCTURE-BASED DESIGN OF PEPTIDE INHIBITORS OF AMYLOID FIBRILLATION
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机译:淀粉原纤化肽抑制剂的结构设计
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摘要
The invention provides methods for designing peptides that inhibit aggregation in target polypeptides. The candidate inhibitory peptidic compounds have an oligomeric sequence that forms energetically-favorable interactions with the amino acid sequence of the steric zipper region of the target protein, and also possess a zipper-disrupting feature that disrupt the peptide stacking at the steric zipper region. This method can be used to obtain inhibitory peptides to disrupt fibril formation involving any protein for which a steric zipper sequence can be identified. The invention also provides inhibitory peptidic compounds, which can be used in pharmaceutical compositions and methods for treating polypeptide aggregation-associated diseases or conditions.
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