Isolated polynucleotide, host cell, protein, oligonucleotide, antibody, processes to produce a protein encoded by the polynucleotide, to determine a polynucleotide that encodes a beta-amyloid peptide-binding protein (bbp) in a sample, to detect in a sample a polypeptide , to diagnose a disease comprising the aberrant expression of human beta-amyloid peptide (bap), to diagnose, to identify compounds that regulate the activity of a beta-amyloid peptide-binding protein and to treat a patient needing to inhibit the accumulation of beta-amyloid peptide in the brain, and, transgenic or chimeric animal.

摘要

"ISOLATED POLYNUCLEOTYDE, HOST, CELL, PROTEIN, OLIGONUCLEOTYDE, ANTIBODY, PROCESSES TO PRODUCE A PROTEIN ENCODED BY POLYNUCLEOTID, TO DETERMINE A POLYNUCLEOTIDE AMETHING A PROTEIN EMITERATOR, EMPTY ATEATTIC EMITERATOR POLYPEPTIDE, TO DIAGNOSE A DISEASE UNDERSTANDING THE OPENING EXPRESSION OF HUMAN BETA-AMYLOID PEPTIDE (BAP), OF DIAGNOSIS, TO IDENTIFY COMPOUNDS THAT REGULATE THE ACTIVITY OF A PEACEFUL BINDING PROTEIN FOR TEPTENTION TREATMENT INHIBIT THE ACCUMULATION OF BETA-AMYLOID PEPTIDE IN THE BRAIN, AND, TRANSGENIC OR CHIMERIC ANIMAL ". New proteins are provided that bind the human β-amyloid peptide, polynucleotides that encode these proteins, and processes for producing these proteins. Diagnostic, therapeutic and evaluation processes are also provided, which employ the polynucleotides and polypeptides of the present invention.