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Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
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机译:具有条件复制起点的环状DNA分子,其制备方法及其在基因治疗中的用途
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摘要
A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterised in that the region allowing the replication thereof has an origin of replication with a functionality in a host cell that requires the presence of at least one specific protein foreign to said host cell. A method for preparing same, cells incorporating said DNA molecules and uses thereof in gene therapy are also described.
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