Imaging Agents for Positron Emission Tomography using radiolabelled with f-18 Aminoalcohol

摘要

New Compounds of Aminoalcohol radiolabelled with f-18 suitable for marking or already labeled with 18F, Methods for the preparation of said Compound, compositions comprising such Compounds, combinations of elements that comprise these compounds or compositions and Uses of these compu These,Compositions and Kits for Diagnostic Imaging by Positron Emission Tomography.Claim 1, characterized because it responds to a compound of formula (1) or Pharmaceutical acceptable salts for use of an inorganic or organic acid of the same Complex, hydrates, solvates, esters, amides, or prodrugs thereof, wherein Y1 is selected from the Group comprising) - N - (A1) Q3 - (CH2) or and (b) - n = C (U1) (U2) Q1,.Q2 and Q3 are selected individually and independently of the Group comprising: a) b) L2 - Hydrogen, c1-4 alkyl, - c) L2 - 4 (d) alquenilo C2 and L2 - alquinilo c2-4; A1 is selected from the Group comprising Methyl ethyl), (b) and (c) L3 U1 and U2 are individually selected and shaped Hood You of the aryl Group that comprises (a), (b) Tert Butyl Hydrogen metilsulfanilo c), d), e) - aryl Halo,(f) Hydroxyl - aryl - aryl nitro, (g), (H) 4 - aryl - and alkyl C1 (i) - 4 - aryl alquiloxi C1, E1 is selected from a group comprising Hydrogen, L2) (b), (c) L2 c1-4 alkyl, (d) alquenilo C2 and L2 - 4 (e) L2 - alquinilo c2-4; L1 is selected from the group consisting of (a) hydrogen, and (b) protecting Group, L2 is u N Group outgoing but not chlorine, Bromine, iodine, or mesyloxy tosyloxy Group; L3 is a protector.U is an integer between 0 and 4, H is an integer between 0 and 3. Claim 1: the use of a compound of Formula 1, wherein it is for the production of drugs or Pharmaceutical compositions for Diagnostic Imaging, more preferably PET Images.Claim 1: a Pharmaceutical composition, which comprises compounds of Formula 1 are acceptable for pharmaceutical use of an inorganic or organic acid of the same Complex, hydrates, solvates, esters, amides, or prodrugs of the same.17: a Vindication of Radiolabelling method to obtain compounds of Formula 3, characterized in that it comprises the step of (a) reacting a compound of Formula 1 with a fluoridation Agent to obtain a compound of Formula 3.