SUBSTITUTED NAPHTHYL INDOLE DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1)

摘要

This invention provides PAI-1 inhibiting compounds of Formula (I): wherein:R1, R2, R3 and R4 are eachH, alkyl, alkanoyl, halo, OH, aryl optionallysubstituted with R8, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino,perfluoroalkoxy; R5 is H, alkyl perfluoroalkyl, aryl optionally substitutedwith R8, alkanoyl, aroyl optionally substituted with R8, R6 is H, alkyl,alkylaryl, benzyl optionally substituted with R8, alkanoyl, aroyl optionallysubstituted with R8, R7 is H, alkyl, alkylaryl, aryl optionally substitutedwith R8, n is 0-6; A is COOH, or an acid mimic such as tetraazole, SO3H,PO3H2, tetronic acid, etc.; R8 is H, alkyl, cycloalkyl, alkanoyl, halo, OH,perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; or apharmaceutically acceptable salt thereof; as well as pharmaceuticalcompositions and methods of treatment using these compounds.