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MUTATIONS IN NOD2 ARE ASSOCIATED WITH FIBROSTENOSING DISEASE IN PATIENTS WITH CROHN'S DISEASE
MUTATIONS IN NOD2 ARE ASSOCIATED WITH FIBROSTENOSING DISEASE IN PATIENTS WITH CROHN'S DISEASE
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机译:患有冠心病的患者中NOD2的突变与纤维化疾病相关
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摘要
PROBLEM TO BE SOLVED: To provide genetic methods for diagnosing mutations linked to the NOD2/CARD15 gene and clinical subtypes of Crohn's disease.SOLUTION: A method of diagnosing a clinical subtype of Crohn's disease characterized by fibrostenosing disease or of predicting susceptibility to the clinical subtype includes a step of determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of or predictive of susceptibility to the clinical subtype of Crohn's disease characterized by fibrostenosing disease. The clinical subtype of Crohn's disease can be, for example, characterized by fibrostenosing disease independent of small bowel involvement.
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