首页> 外国专利> METHOD OF PREDICTING EFFICIENCY OF TREATMENT OF PATIENTS WITH CHRONIC BRAIN ISCHEMIA AND TYPE 2 DIABETES MELLITUS WITH PHARMACOLOGIC PREPARATION MILDRONAT

METHOD OF PREDICTING EFFICIENCY OF TREATMENT OF PATIENTS WITH CHRONIC BRAIN ISCHEMIA AND TYPE 2 DIABETES MELLITUS WITH PHARMACOLOGIC PREPARATION MILDRONAT

机译:预测慢性脑梗死和2型糖尿病患者合并药代动力学的治疗效率的方法

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to pharmacotherapy and deals with method of predicting efficiency of treatment of patients with chronic brain ischemia and type 2 diabetes mellitus with pharmacologic preparation mildronate. Essence of method lies in determining in patient's blood erythrocytes activity of glutathione peroxidase (GPO). If values of GPO activity are lower than 23.7±2.23 nmol/min per 1 mg of protein, efficient treatment with mildronat is predicted. If values of GPO activity are higher than said value, treatment with mildronate is predicted to be inefficient.;EFFECT: method application provides possibility of individual prediction of efficiency of treatment with mildronat of patients with chronic brain ischemia and diabetes mellitus.;2 tbl, 2 ex
机译:药物发明领域本发明涉及药物,即药物疗法,并涉及用药代丙二酸酯治疗预测慢性脑缺血和2型糖尿病患者的疗效的方法。方法的实质在于确定患者血液中谷胱甘肽过氧化物酶(GPO)的活性。如果每1 mg蛋白质的GPO活性值低于23.7±2.23 nmol / min,则可以预测用亚硝酸盐有效治疗。如果GPO活性值高于所述值,则预测用次膦酸盐治疗无效。;效果:该方法的应用提供了个体预测慢性脑缺血和糖尿病患者用次膦酸盐治疗效率的可能性。2tbl, 2前

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