BICYCLIC HETEROCYCLIC DERIVATIVES AND THEIR USE AS INHIBITORS OF STEAROYL-COA-DESATURASE (SCD)

摘要

PROBLEM TO BE SOLVED: To provide new classes of compounds that are useful in modulating SCD activity and regulating lipid levels.SOLUTION: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise, for example, a process of administering to a mammal in need thereof a compound of formula (I): where x, y, J, K, L, M, W, V, R, R, R, R, R, R, R, R, Rand Rare defined in the specification. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.