Set of markers for the detection of hepatic metastases of colorectal cancer and kit for detecting liver metastases of colorectal cancer.

摘要

Set of markers for the detection of hepatic metastases of colorectal cancer and kit for detecting liver metastases of colorectal cancer. # The present invention relates to a set of markers for the detection of hepatic metastases in patients with colorectal cancer. This assembly, including the marker DCC (18q21.3) known in the literature, further comprising the ASAPl ​​(8q24.1-q24.2), ZMYM2 (13qll-q12), MYBL2 (20q13.1), TDP52L2 (markers 20qtel) and SMAD4 (18q21.1). Optionally also includes MSRI (8p22), TNKS (8p23.1), CYP24A1 (20q13) and / or AURKA (20q13.2-13.3) markers. This set of markers was chosen from results obtained by various methods as the CGHa low and high density, Q-PCR and FISH, where the results of Q-PCR were analyzed facing the absolute and relative method of this analysis. a kit for detection of liver metastasis in colorectal cancer patients comprising this set of markers is also presented.