METHOD FOR COMPUTING PHARMACOKINETIC PARAMETERS IN MRI

摘要

The present invention relates to a method of dynamic contrast magnetic resonance imaging aimed to improve characterization of tissue image by improving accuracy of computed pharmacokinetic parameters such as K^trans (transfer constant across capillary membrane; a pharmacokinetic parameter of tissue perfusion) using T1W Fast DCE-MRI technique to distinguish between malignant, benign and normal tissues. A phantom and a contrast agent are used in the proposed MRI system for computing accurate T₁ value of a tissue after the contrast is injected based on an intrinsic T₁₀ value the tissue, wherein the intrinsic T₁₀ value is adjusted and/or normalized to improve accuracy of the T₁ value computed, which in turn is used for computation of pharmacokinetic parameters at least one of K^trans.