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METHOD FOR COMPUTING PHARMACOKINETIC PARAMETERS IN MRI
METHOD FOR COMPUTING PHARMACOKINETIC PARAMETERS IN MRI
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机译:MRI中药动学参数的计算方法
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摘要
The present invention relates to a method" of dynamic contrast magnetic resonance imaging aimed to improve characterization of tissue image by improving accuracy of computed pharmacokinetic parameters such as Ktrans (transfer constant across capillary membrane; a pharmacokinetic parameter of tissue perfusion) using T1W Fast DCE-MRI technique to distinguish between malignant, benign and normal tissues. A phantom and a contrast agent are used in the proposed MRI system for computing accurate T1 value of a tissue after the contrast is injected based on an intrinsic T10 value the tissue, wherein the intrinsic T10 value is adjusted and/or normalized to improve accuracy of the T1 value computed, which in turn is used for computation of pharmacokinetic parameters at least one of Ktrans.
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机译:本发明涉及一种动态对比磁共振成像的方法,该方法旨在通过使用T1W Fast DCE-通过提高计算的药代动力学参数如Ktrans(跨毛细血管膜的转移常数;组织灌注的药代动力学参数)的准确性来改善组织图像的表征。 MRI技术区分恶性组织,良性组织和正常组织,在拟议的MRI系统中使用幻像和造影剂根据组织的内在T10值计算注入造影剂后组织的准确T1值,其中调节和/或归一化T10值以提高所计算的T1值的准确性,该T1值又用于计算至少Ktrans之一的药代动力学参数。
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