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SIMULTANEOUS ASSAY METHOD OF MULTIPLEX CYTOCHROME P450 ENZYME ACTIVITY IN A BIOSAMPLE BASED ON MASS SPECTROMETRY
SIMULTANEOUS ASSAY METHOD OF MULTIPLEX CYTOCHROME P450 ENZYME ACTIVITY IN A BIOSAMPLE BASED ON MASS SPECTROMETRY
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机译:基于质谱的同时检测生物样品中多种细胞色素P450酶活性的方法
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摘要
PURPOSE: A simultaneous assay method of multiplex cytochrome P450 enzyme activity is provided to simultaneously measure the activity change of various cytochrome P450 enzymes and to study diseases related to the cytochrome P450 enzyme activity.;CONSTITUTION: A simultaneous assay method of multiplex cytochrome P450 enzyme activity comprises: a step of simultaneously extracting steroid hormone metabolic products including male hormones, female hormones, corpus luteum hormones, sterol, and adrenal cortical hormones from urine; a step of re-extracting the extracts using an organic solvent and performing trimethyl silyl derivatization; and a step of measuring the concentration of steroid hormone biometabolic products in the urine by gas chromatography-mass spectrometer.;COPYRIGHT KIPO 2013;[Reference numerals] (AA) Before dosing a drug; (BB) After dosing a drug;
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