TRANSITION METAL OXIDE/TANTALUM OXIDE CORE/SHELL NANOPARTICLE CAPABLE OF APPLYING TO EFFECTIVE CANCER TREATMENT, A PRODUCTION METHOD THEREOF, AND AN X-RAY CT CONTRAST AGENT AND MRI T2 CONTRAST AGENT INCLUDING THE SAME

摘要

PURPOSE: A transition metal oxide/tantalum oxide core/shell nanoparticle is provided to be used as an X-ray CT contrast agent and an MRI T2 contrast agent by combining a biocompatible molecule or ligand on the surface of a tantalum oxide shell.;CONSTITUTION: A core/shell nanoparticle comprises a transition metal oxide core and a tantalum oxide shell. The transition metal oxide is selected from ferric oxide, manganese oxide, ceria, titanium oxide, nickel oxide, cobalt oxide, and zinc oxide. The size of the transition metal oxide is 1-100 nm, and the thickness of the tantalum oxide shell is 1-50 nm. A silane group or a phosphine group is combined to the surface of the tantalum oxide shell, and a functional material is combined to the silane group or the phosphine group. The functional material is selected from a biocompatible material, organic dye, a bioactive material, a functional group, an organic molecule, organic metal, a nanoparticle, a shell structure, or a combination thereof.;COPYRIGHT KIPO 2013