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Process for preparing lymphocytes comprising activated natural killer cells for targeting cancer cells and pharmaceutical composition comprising the same
Process for preparing lymphocytes comprising activated natural killer cells for targeting cancer cells and pharmaceutical composition comprising the same
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机译:制备用于靶向癌细胞的包含活化的自然杀伤细胞的淋巴细胞的方法以及包含该淋巴细胞的药物组合物
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摘要
The present invention relates to a method for producing lymphocytes including NK cells, the capability of producing interferon-? of which is significantly enhanced, by culturing mononuclear cells in the presence of gamma globulin. In particular, the present invention relates to a method for producing lymphocytes including activated natural killer cells for targeting cancer cells that express HER2/neu antigen such as breast cancer and ovarian cancer, by binding an anti-HER2/neu antibody to a lymphocyte having activated natural killer cells, and also relates to a pharmaceutical composition including same.
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