METHOD FOR CREATING EXPERIMENTAL MODEL OF OSTEOPOROSIS IN RABBIT

摘要

FIELD: medicine.;SUBSTANCE: modelling in rabbits is performed by one-side ovarioectomy and introduction of hydrocortisone 3 days later. Hydrocortisone is injected under the regimen: 1^st, 14^th days 0.1 ml (mg); 2^nd, 3^rd, 12^th, 13^th days - 0.2 ml (mg); 4^th-11^th days 0.3 ml (mg).;EFFECT: method provides creating an adequate model of osteoporosis with decreased mortality rate in experimental animals and manifestations of hormone withdrawal syndrome.;2 dwg