Search algorithm for epistasis effect based on comprehensive genome-wide SNP information

摘要

PPROBLEM TO BE SOLVED: To provide a method of identifying an SNP pair having synergistic epistasis effects within an actual time, even when main effects are not confirmed with respect to a binary phenotype by using genome side SNP data. PSOLUTION: The binary phenotype data of each specimen are input and stored (1). The genotype of M pieces of single nucleotide polymorphism (SNP) with respect to each specimen are input and stored (2). Genotype-categorized counting is calculated for every phenotype with respect to each SNP (3). The genotype-categorized counting is stored by determining the validity/invalidity of analysis continuation with respect to each SNP (4). Dominant/recessive type for the phenotype is determined and stored with respect to the SNP determined to be valid for analysis continuation (5). The epistasis effects are determined and stored based on a division table based on a division table based on the phenotype and the dominant/recessive type with respect to the two SNP determined to be valid for analysis continuation, and the SNP pair to be analyzed is changed according to an analytic procedure (6). The epistasis effects are verified by logistic regression analysis with respect to the SNP pair whose epistasis effects are determined (7). PCOPYRIGHT: (C)2011,JPO&INPIT