Procedure for the synthesis of 3 - 3 - (7S) - 3,4 - dimetoxibiciclo 4.2.0 octa - 1,3,5 - triennium 2008-2010 - 7 - il methyl} (methyl) amino propyl - 7.8 - Dimethoxy - 1,3,4,5 - tetrahydro - 2H - 3 - benzazepin - 2 - One (Combination).

摘要

Preparing (P1) ivabradine (I) involves reductive amination reaction of 4-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-butyraldehyde (V) with ((S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1(6),2,4-trien-7-ylmethyl)-methyl-amine (VI) in the presence of an iron-based catalyst, optionally in the presence of trimethylamine N-oxide, under dihydrogen pressure of 1-20 bars, in an organic solvent or mixture of organic solvents, at 25-100[deg] C. ACTIVITY : Cardiant; Vasotropic; Antianginal. No biological data given. MECHANISM OF ACTION : None given.