Tetrahidroisoquinolina substituted Compounds, inhibitors of the coagulation factor XIa (fxia); Pharmaceutical composition that comprises; and its use for the treatment of an inflammatory or selected thromboembolic disorder of unstable angina, Acute Coronary Syndrome and fibrillation On atrial, among others.

摘要

The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.