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摘要

The present invention relates to the genetic structure, procedure, preparation and application of new yeast strains for synthesis or Modified steroids. More specifically, the present invention describes a strain that reduces activity by displaying 20A-HSD types, mainly by altering genes gcy1 and/or ypr1.The yeast strain of this invention increases the efficiency of synthesis or increases the selectivity or benefit of the process. As the quality of the final product.The compounds of the present invention are effective research, development and production products with therapeutic or preventive effects; In humans and animals, especially steroid derivatives.