Osmotic pump tablet with controlled porosity of highly permeable drugs and their preparation procedure

摘要

Osmotic pump tablet of controlled porosity of highly permeable drugs, comprising a core and a semipermeable membrane, in which the core comprises a main agent, wherein said main agent is venlafaxine or a pharmaceutically acceptable salt thereof, an enhancer of the permeation and unuxiliar permeation, and the semipermeable membrane comprises a film-forming material and a pore-forming agent, wherein the semipermeable membrane comprises the pore-forming agent in an amount comprised between 20 and 45% by weight of the semipermeable membrane , wherein said depot forming agent is selected from the group consisting of polyethylene glycol with a molecular weight of 2000 to 6000, hydroxypropyl cellulose, and mixtures thereof, and the semipermeable membrane is present in an amount between 10 and 35% in core weight