NEW CRYSTAL FORMS 4,4'- 4-FLUOR-7 ({4- 4- (3-fluorine-2-methylphenyl) butoxy phenyl} ethynyl) -2-methyl-1-1H-indol-1,3 -DIELE DIBUTANIC ACID, 4,4 '- 2-METHYL-7 - ({4- 4- (PENTAFLUOROPHENYL) BUTOXY Phenyl} Ethynyl) -1H-INDOL-1,3-DIYL DIBUTANIC ACID AND 4, 4 '- 4-Fluoro-2-methyl-7 - ({4- 4- (2,3,4,6-tetrafluorophenyl) butoxy phenyl} ethynyl) -1H-indole-1,3-diyl dibutane ACIDS

摘要

1. The crystalline form of 4,4 '- [4-fluoro-7 - ({4- [4- (3-fluoro-2-methylphenyl) butoxy] phenyl} ethynyl) -2-methyl-1H-indole-1,3 -diyl] dibutanoic acid having at least peaks in the X-ray powder diffraction spectrum at diffraction angles (2θ) of about 7.29, 10.24, 12.15, 17.95 and 18.44.2. Crystalline Form 4,4 '- [4-fluoro-7 - ({4- [4- (3-fluoro-2-methylphenyl) butoxy] phenyl} ethynyl) -2-methyl-1H-indole-1,3-diyl ] dibutanoic acid according to claim 1, having peaks at diffraction angles (2θ) of about 6.41, 7.29, 9.22, 10.03, 10.24, 12.15, 12.59, 13.36, 13.88, 14.15, 14.44, 16.60, 17.33, 17.95, 18.44, 18.86, 19.27, 20.23, 21.10, 21.85, 22, 26, 23.11, 23.63 and 24.38 in the powder X-ray diffraction spectrum. 3. Crystalline Form 4,4 '- [4-fluoro-7 - ({4- [4- (3-fluoro-2-methylphenyl) butoxy] phenyl} ethynyl) -2-methyl-1H-indole-1,3-diyl ] dibutanoic acid according to claim 2, characterized by a powder X-ray diffraction spectrum shown in FIG. 3.4. Crystalline Form 4,4 '- [4-fluoro-7 - ({4- [4- (3-fluoro-2-methylphenyl) butoxy] phenyl} ethynyl) -2-methyl-1H-indole-1,3-diyl ] dibutanoic acid having an endothermic peak at about 157 ° C in the spectrum obtained by differential scanning calorimetry. 5. Crystalline Form 4,4 '- [4-fluoro-7 - ({4- [4- (3-fluoro-2-methylphenyl) butoxy] phenyl} ethynyl) -2-methyl-1H-indole-1,3-diyl ] dibutanoic acid according to claim 4, characterized by a spectrum of differential scanning calorimetry shown in Fig.6.6. The crystalline form of 4,4 '- [2-methyl-7 - ({4- [4- (pentafluorophenyl) butoxy] phenyl} ethynyl) -1H-indole-1,3-diyl] dibutanoic acid having an X-ray diffraction spectrum on the powder, at least peaks at diffraction angles (2θ) of about 5.12, 10.16, 10.51, 14.90 and 20.42.7. The crystalline form of 4,4 '- [2-methyl-7 - ({4- [4- (pentafluorophenyl) butoxy] phenyl} ethynyl) -1H-indole-1,3-diyl] dibutanoic