3-CARBOXAMIDE-4-OXOQUINOLINE DERIVATIVES, USEFUL AS MODULATORS OF REGULATOR OF TRANSMEMBRANE CYSTIC FIBROSIS CONDUCTIVITY

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to formula compound or to its pharmaceutically acceptable salt, where R represents COOH or CH₂OH. Invention also relates to pharmaceutical composition based on formula I, method of modulating CFTR activity in biological sample, based on application of formula I compound, method of treatment, based on application of formula I compound, set based on formula I compound.;EFFECT: obtained are novel derivatives of quinolin-4-one, useful as CFTR modulators.;18 cl, 1 tbl, 8 ex