Tumor prevention and therapy by induction of tumor senescence

摘要

The present invention relates to a combination of at least two different substances, one of which activates the STAT1 signaling cascade, and the other activates the TNFR1 / CD95 signaling cascade, for the induction of a permanent growth arrest - that is, a senescence - in premalignant or malignant tumors or tumor cells. This induction of sustained growth arrest is not dependent on cytotoxicity and does not primarily attempt to kill tumor cells, although this may occur. It is used for the treatment and / or prevention of tumors by growth arrest; According to the invention, the combination is used for therapeutic or preventive senescence induction in tumors in which the STAT1 and TNFR1 / CD95 signaling cascade is activatable and p16Ink4a is present. The invention converts tumor cells and - in contrast to many other therapies, including the tumor stem cells - in a permanent Wachtumsarrest.