synthetic polypeptide library Oyobi natural de variety mosquitoes are other polypeptide variant wo prepared to reservoir mounting method

摘要

Composition for generating a library of DNA sequences encoding the homologous polypeptides and methods, and the present invention provides the use of said library to identify the polypeptide variant has been diversified in nature. The present invention, a composition for making a collection of synthetic antibody fragment was replaced by the collection of the corresponding CDR captured from natural sources and complementarity determining regions of one or several 1 (CDR) is a method provide. Furthermore, by not necessary to modify the polypeptide coding sequence of the original and insert sequences are diverse synthetic or natural origin, a composition for diversifying a portion of a polypeptide and the invention provides a method to.