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Thiol-ene click chemistry for drug conjugates
Thiol-ene click chemistry for drug conjugates
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机译:药物偶联物的硫醇-点击化学
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摘要
The present invention relates to linker molecules that readily conjugate cellular recognition ligand at one end and drug payload at the other, and are useful in treating or preventing cancer, an autoimmune disease, an inflammatory condition, a central nervous system disorder or an infection. The linker inker molecules of the invention are represented by Formula I, II and III; Linker-Drug compounds represented by Formula IV, V and VI; and Ligand-Linker-Drug conjugates represented by Formula VII, VIII and IX:; 展开▼