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Broad spectrum vaccine against typhoidal and non-typhoidal Salmonella disease
Broad spectrum vaccine against typhoidal and non-typhoidal Salmonella disease
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机译:抗伤寒和非伤寒沙门氏菌疾病的广谱疫苗
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摘要
The present invention is drawn to multivalent Salmonella enterica serovar conjugate vaccines comprising conjugates of S. Typhimurium, S. Enteritidis, S. Choleraesuis, S. Typhi, S. Paratyphi A and optionally S. Paratyphi B, wherein the conjugates comprise a hapten antigen and a carrier antigen, wherein at least one of the hapten antigens or carrier antigens is characteristic of the Salmonella enterica serovar. The present invention also provides Salmonella enterica serovar reagent strains to produce the multivalent conjugate vaccines and attenuated Salmonella enterica serovars for use as vaccines.
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