Methods for detecting and modulating the sensitivity of tumour cells to anti-mitotic and/or dna damaging agents and compositions which enhance the sensitivity of tumour cells to said agents

摘要

A method of screening a tumour cell for resistance to a tubulin-binding agent, the method comprising detecting the expression of any one or more of class II, class III and class IVb ²-tubulin by the tumour cell, wherein the expression of any one or more of class II, class III and class IVb ²-tubulin indicates that the tumour cell has resistance or potential resistance to the tubulin-binding agent.