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Method of predicting a predisposition to developing alcoholism or excessive drinking and a composition for treatment of alcohol-related disease
Method of predicting a predisposition to developing alcoholism or excessive drinking and a composition for treatment of alcohol-related disease
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机译:预测易患酒精中毒或过度饮酒的方法以及用于治疗酒精相关疾病的组合物
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摘要
The gene responsible for encoding SERT has a functional polymorphism at the 5-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3 UTR SNP rs 1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.
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机译:负责编码SERT的基因在5调控启动子区域具有功能性多态性,导致长(L)和短(S)两种形式。据推测,LL基因型在早期饮酒中起关键作用。本发明公开了基于L或短基因型以及基于SERT基因的3 UTR SNP rs 1042173的单核苷酸多态性在治疗和诊断上的差异。本发明证明了使用药物恩丹西酮和类似物的功效基于SERT基因多态性变异的治疗药物,以及诊断滥用酒精和其他与成瘾相关的疾病和障碍的易感性的方法。
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