Combination therapy for the treatment of sleep apnea associated with obesity

摘要

Combination of a therapeutically effective amount of an anticonvulsant sulfamate derivative with a therapeutically effective amount of a sympathomimetic agent for use in a method of treating sleep apnea associated with obesity and / or X syndrome, in which the derivative of anticonvulsant sulfamate has a structure of formula (I) ** Formula ** in which X is CH2 or O, R1 is hydrogen or R2 alkyl, R3, R4 and R5 are independently H or C1-C3 alkyl, and further in which when X is O, then R2 and R3, and / or R4 and R5, can be taken together to form a methylene-dioxyl bond of formula -O-CR6R7-O- where R6 and R7 are independently H or C1-C3 alkyl , or they can be taken together to form a cyclopentyl or cyclohexyl ring, and the sympathomimetic agent is selected from phenylethylamine, epinephrine, norepinephrine, epinine, dopamine, dobutamine, nordephrine, ethylnorepinephrine, isoproterenol, protoquilol, isoetarin, metaproterenol, terbuterol, aminol, phenylephrine, tyramine, hydroxy amphetamine, methoxyphenamine, methoxamine, albuterol, amphetamine, methamphetamine, benzphetamine, ephedrine, phenylpropanolamine, mephentermine, phentermine, chlorphentermine, fenfluramine, propylhexedrine, phenmetrazine, and phenmetrazine.