CATULIN AS A MARKER AND THERAPY TARGET FOR HIGHLY MOTILE SQUAMOUS CELL CARCINOMA METASTATIC CELLS AND NORMAL WOUND HEALING

摘要

Provided are methods of detecting metastatic cancer in a subject. The method may include measuring an amount of catulin in a sample from the subject; and comparing the amount of catulin in the sample to an amount of catulin in a control, wherein an increased level of catulin in the sample relative to the amount in the control indicates metastatic cancer in the sample. Further provided are methods of treating metastatic cancer. The method may include administering to a subject an effective amount of a therapeutic composition adapted to reduce the amount or the activity of catulin. The cancer may comprise squamous cell carcinoma. The cancer may comprise breast cancer. The amount of catulin in the sample may be measured by catulin antigen-antibody binding.