Skin irritation factor with yellow sands and the methods for inducing the skin irritation and screening the material of inhibiting the skin irritation factor alleviating the skin irritation in the keratinocyte and the composition for skin external application containing the material screened by the method

摘要

The present invention relates to a method for screening substances involved in inducing skin irritation caused by yellow dust by screening substances having significantly increased expression levels by treating yellow corpuscular cells with keratinocytes, A method for inducing skin irritation caused by yellow dust, a method for alleviating skin irritation caused by yellow dust by inhibiting the expression of AhR or CYP in mammals, and a method for skin irritation caused by yellow dust by measuring the degree of skin irritation factor A method for screening a substance that alleviates skin irritation caused by yellow sand, and a method for screening a substance that alleviates skin irritation caused by yellow sand, as an active ingredient.;Yellow dust, keratinocyte, keratinocyte, AhR, CYP, overin, gout, skin irritation