APPLICATION OF PRDX2 AND / OR PRDX6 TO PRODUCE A PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DAMAGE, AGING OR DISEASE CAUSED BY INCREASING THE LEVEL OF ACTIVE OXYGEN FORMS

摘要

1. The use of hydrogen peroxide oxidoreductase to obtain a pharmaceutical composition for treating or preventing damage, aging or diseases resulting from an increase in the content of reactive oxygen species (ROS), where the hydrogen peroxide oxidoreductase contains PRDX2 protein and / or PRDX6.2 protein. The use of claim 1, wherein the pharmaceutical composition is used as (1) a cell protecting agent, an organ protecting agent, or a tissue protecting agent; (2) a medicament for improving sperm quality in patients suffering from asthenospermia or treating male infertility; (3) anti-aging drug or cosmetic, for scar healing, anti-wrinkle treatment, wrinkle removal, lightening freckles, whitening, sun protection or skin cancer prevention; (4) medicine for treating burns, areas scalding or damage to the cornea; (5) drugs to accelerate the healing process; or (6) a medicinal or medical product to protect tissues or cells from oxidative damage. 3. The use of claim 1, wherein the PRDX2 protein is a mammalian PRDX2 protein or active fragments or derivatives thereof; and the PRDX6 protein is a mammalian PRDX6 protein or active fragments or derivatives thereof. The use according to claim 1, wherein the PRDX2 protein comprises a protein whose amino acid sequence is represented by SEQ ID NO: 4, or a fragment represented by SEQ ID NO: 4 at positions 6 to 164, or a fusion protein thereof formed with an expression sequence; PRDX6 protein includes a protein whose amino acid sequence is represented by SEQ ID NO: 2, or a fragment