ERYTHROBLAST ENUCLEATION METHOD, AND ENUCLEATED ERYTHROCYTE MAINTENANCE METHOD

摘要

PROBLEM TO BE SOLVED: To provide a method of inducing enucleation positively in a short time, and a method of improving the survival rate of enucleated erythrocyte.;SOLUTION: The invention provides an enucleation method of erythroblast, and/or maintenance method of enucleated erythrocyte, which is characterized by culturing hematopoietic progenitors, erythrocytic progenitors, and/or erythroblasts with a medium under 1.0-18.0% oxygen conditions; a method where the medium is under 2.0-10.0% oxygen conditions; a method where the culture medium contains a compound proopiomelanocortin (POMC); and a method where the compound is ACTH.;SELECTED DRAWING: None;COPYRIGHT: (C)2016,JPO&INPIT