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Single particle detection apparatus using optical analysis, single particle detection method, and computer program for single particle detection
Single particle detection apparatus using optical analysis, single particle detection method, and computer program for single particle detection
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机译:利用光学分析的单颗粒检测装置,单颗粒检测方法以及用于单颗粒检测的计算机程序
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摘要
There is provided a single particle detection technique based on a scanning molecule counting method, enabling individual detection of a single particle using light measurement with a confocal microscope or multiphoton microscope, and quantitative observation of conditions or characteristics of the particle. The inventive technique of detecting a single particle in a sample solution is characterized by detecting light containing substantially constant background light from a light detection region with moving the position of the light detection region of the microscope in a sample solution to generate time series light intensity data; and detecting individually a light intensity reduction occurred when a single particle which does not emit light (or a particle whose emitting light intensity in a detected wavelength band is lower than the background light) enters in the light detection region in the time series light intensity data as a signal indicating the existence of each single particle.
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