Electrochemical Detection of Single A-G Mismatch Using Biosens-ing Surface Based on Gold Nanoparticles

摘要

The study of small drug molecules interacting with nucleic acids is an area of intenseresearch that has particular relevance in our understanding of relative mechanismin chemotherapeutic applications and the association between genetics (includingsequence variation) and drug response. In this contribution, we demonstrate howthe sequence-specific binding of an anticancer drug Dacarbazine (DTIC) to singlebase (A-G) mismatch could be sensitively detected by combining electrochemicaldetection with biosensing surface based on gold nanoparticles.