Cross-reference of applications related to immune competence assessment by adaptive immune receptor diversity and clonal characterization

摘要

Identify rearranged DNA (and / or subsequently transcribed RNA) sequences encoding T cell receptor (TCR) and / or immunoglobulin (IG) polypeptides in lymphoid DNA-containing samples from subjects And a method for determining the immunological status of the subject's adaptive immune system by quantifying. TCR and / or IG sequence diversity and sequence distribution allow assessment of immune competence and immune repertoire and reflect the extent of T cell or B cell clonal and clonal expansion in the sample. Also described is a method for stratifying patient populations based on immune capacity, including possible response to immunotherapy. [Selection] FIG. 11A