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Cross-reference of applications related to immune competence assessment by adaptive immune receptor diversity and clonal characterization
Cross-reference of applications related to immune competence assessment by adaptive immune receptor diversity and clonal characterization
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机译:通过适应性免疫受体多样性和克隆特征与免疫能力评估相关的应用程序的交叉引用
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摘要
Disclosed are methods for determining the immunological status of the adaptive immune system of a subject by identifying and quantifying rearranged DNA (and/or subsequently transcribed RNA) sequences encoding T cell receptor (TCR) and/or immunoglobulin (IG) polypeptides, in a lymphoid DNA-containing sample from the subject. TCR and/or IG sequence diversity and sequence distribution permit immunocompetence and immune repertoire assessment and reflect the degree of T cell or B cell clonality and clonal expansion in the sample. Methods for stratifying patient populations on the basis of immunocompetence including likelihood of responding to immunotherapy are also described.
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