METHOD FOR PREDICTING EFFICIENCY OF TREATMENT OF PATIENTS WITH NON-HODGKIN HIGH-GRADE LYMPHOMA

摘要

The invention relates to the field of medicine, in particular, to medical genetics, oncology and oncohematology. The essence of the disclosed method consists in the following: polymorphism G13494A of 6-th intron of patient's TP53 gene is analysed and in case if homozygous genotype G/G is detected in patient in the said locus, low efficiency of treatment is predicted, namely low probability of 5-year patient's survival and low probability of recurrence absence, and in case of detecting in patient genotype A/A or G/A in the said locus, high efficiency of treatment, namely high probability of remission occurrence and 5-year patient's survival, is predicted. The disclosed method is efficient with respect to different variants of aggressive NHL, is technically simple, makes it possible to obtain more complete picture of treatment efficiency prediction (probability of achieving remission, patients' survival for 5 years from the date of diagnosing, as well as probability of patients' survival for the said time period without recurrence).