6,7,8,9-四氢-5H-苯并7轮烯-2-烷基胺类化合物及其用途 6,7,8,9-TETRAHYDRO-5H-BENZO7 ANNULENE-2-ALKYLAMINE COMPOUND AND USE THEREOF

摘要

Provided are a 6,7,8,9-tetrahydro-5H-benzo[7] annulene-2-alkylamine compound represented by formula I and or a pharmaceutically acceptable salt thereforeof, and a use thereof. The compound exhibits strong inhibitory activity foragainst the synthesis of thea golden -colored pigment ofby Staphylococcus aureus (S. aureus). The golden -colored pigment of Staphylococcus aureus can help assist S.taphylococcus aureus escape from to avoid being killed by the reactive oxygen produced by the human innate immune system, and is a key virulence factor determining the pathogenic abilitypathogenicity of bacteria. The golden- colored pigment can also increase the resistance of bacteria to oleic acid, and can increase the virulence of bacteriathereof by improving the antioxidative capabilities performance of bacteriathereof. Inhibiting synthesis of the golden -colored pigment, a the virulence factor of S.taphylococcus aureus, is a new and effective antibacterial agent strategy. By targeted inhibition of synthesis of the golden -colored pigment, the compound of the present invention is expected to be developed into a novel antibacterial agent in single administrationfor monotherapy, and can also be developed into an antibacterial agent for in combined administrationcombination therapy together with existing antibiotics.