CONTROLLABLY DEGRADABLE MULTI-(AMINO ACID) COPOLYMER-ORGANIC CALCIUM/PHOSPHOR SALT FILLING-TYPE COMPOSITE BONE IMPLANT AND PREPARATION METHOD

摘要

A controllably degradable multi-(amino acid) copolymer-organic calcium/phosphor salt filling type composite bone implant and a preparation method. The composite bone implant consists of a multi-(amino acid) copolymer and a medically acceptable organic calcium/phosphor salt component. The organic calcium/phosphor salt accounts for 20-90% of the total mass of the composite material; the multi-(amino acid) copolymer is formed by polymerizing ε-aminocaproic acid and at least two other amino acids; the ε-aminocaproic acid accounts for at least 50% of the total molar weight of the amino acid copolymer; the other amino acids account for at least 0.5% of the total molar weight of the amino acid copolymer respectively. The composite bone implant is more suitable for the healing and repairing period of a human body's natural bone, the pH value of a soaking liquid of the composite bone implant after degradation is 6.5-7.5, the partial physiological environment is slightly affected, irritative reaction is not caused, and the cell growth and the tissue repair are facilitated.