Direct conversion method of mesenchymal stromal stem cells to endothelial cells by defined transcription factors

摘要

The present invention relates to a method for converting mesenchymal stem cells into endothelial cells by using specific transcription factors. More specifically, the present invention relates to a method for converting mesenchymal stem cells into endothelial cells by using specific transcription factors such as Oct4, Nanog, Tal1 and LMO2. According to the present invention, two kinds of genes that are not directly related to cancer induction among the reprogramming factors of the cell and the other two types of transcription factors that are not expressed in mesenchymal stem cells or are expressed at low levels among the transcription factors related to vascular development are selected and combined such that a method for converting mesenchymal stem cells such as adult cells or adult stem cells into endothelial cells is developed, and thus, the method has an effect of being applied to the production of endothelial cells to constitute regenerative tissue in tissue engineering and the treatment of ischemic diseases.