compound, pharmaceutical composition, lecithin cholesterol acyltransferase activator, anti-atherosclerotic agent, prophylactic or therapeutic agent for atherosclerosis, agent for lowering blood ldl cholesterol concentration and for raising blood hdl cholesterol concentration, use of a compound, and, methods for activating lecithin-cholesterol acyltransferase, and for the treatment or prophylaxis of a disease.

摘要

A compound represented by the general formula (I) or a pharmacologically acceptable salt thereof has an excellent LCAT-activating effect and is useful as an active ingredient in a therapeutic or prophylactic agent for arteriosclerosis, arteriosclerotic heart disease, coronary heart disease (including heart failure, myocardial infarction, angina pectoris, cardiac ischemia, cardiovascular disturbance, and restenosis caused by angiogenesis), cerebrovascular disease (including stroke and cerebral infarction), peripheral vascular disease (including diabetic vascular complications), dyslipidemia, hypo-HDL-cholesterolemia, or renal disease, particularly, an anti-arteriosclerotic agent, wherein R is an optionally substituted aryl group or an optionally substituted heteroaryl group.