Solid scattering produced by fusion, which contains an apocalypse inducer

摘要

It refers to the dispersion of solid-state exopolymers containing one (I) prepared elicitor.R0 is halogen; R1 and R2 are h, methyl or Metohija; R3 and R4 are methyl or Metohija; R1 and R2 are h, or h, if R1 and R2 are methyl or Metohija; A1 and A2 are ch or N; R5 is C1-C4 tar or halotar; X is - o-o-nh;This is - (CH2) n -;N is 0, 1, 2 or 3; R6 is a carbon thyroid ring or non ring ring ring with three or seven alternative members. 1. This is a selected compound of 4 - (4 - [2 - (4-chlorophenyl) - 4,4-dimethoxyethane-1-en-1-il) - methyl - (1h-indy-5-iloki) - 2 - (1h-indy-5-iloki) - N - ({3-nitro-4 - (1-tetrahydro-2h-piran-4-ilpiperidin-4-il) amine) / fenil);There are others The compound is an inhibitor of the bcl-2 protein family dispersed in a single matrix, including (a) a polygonal vehicle dissolved in water acceptable for drugs and (b) a surfactant acceptable for drugs. It also refers to a preparation process, including placing the compounds of formula I (a) and (b) at high temperature,To provide a semi-solid isomerized mixture; to extrude the semi-solid mixture; and to cool the resulting isomer to provide a solid matrix, including polygonal vehicles and surfactants, in which the compound is dispersed in a substantially amorphous form. This dispersion is useful in the treatment of cancer, mesothelioma and other new plastic diseases.