首页> 外国专利> IN VITRO METHOD AND KIT FOR THE PROGNOSIS OR PREDICTION OF THE RESPONSE TO TREATMENT WITH ANTI-PSYCHOTIC AGENTS IN PATIENTS WHO HAVE SUFFERED FIRST EPISODE PSYCHOSIS

IN VITRO METHOD AND KIT FOR THE PROGNOSIS OR PREDICTION OF THE RESPONSE TO TREATMENT WITH ANTI-PSYCHOTIC AGENTS IN PATIENTS WHO HAVE SUFFERED FIRST EPISODE PSYCHOSIS

机译：体外方法和试剂盒用于预防或预测患有首发性精神分裂症的患者对抗精神分裂症药物治疗的反应

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摘要

The present invention relates to an in vitro method for the prognosis or prediction of the response to treatment with anti-psychotic drugs in subjects who have suffered first episode psychosis (FEP), and specifically to the use of the expression value, in a biological sample isolated from said subjects, of the ratio formed by two of the isoforms – active isoform and truncated isoform – of the receptor (TrKB) of the nerve growth factor BDNF, named TrKB-FL and TrkB-T, respectively. The present invention also describes kits and uses of same to implement the method of the invention. 展开▼

机译：本发明涉及一种体外方法，其用于在患有第一次发作性精神病（FEP）的受试者中预后或预测对使用抗精神病药治疗的反应，特别是涉及在从上述受试者中分离出的生物学样本中，神经生长因子BDNF受体（TrKB-FL和TrkB-T）的两个同工型（活性同工型和截短同工型）形成的比率的表达值，分别。本发明还描述了试剂盒及其用于实施本发明方法的用途。 展开▼

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公开/公告号WO2016207466A1

专利类型

公开/公告日2016-12-29

原文格式PDF

申请/专利权人 CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED;UNIVERSIDAD DEL PAÍS VASCO/EUSKAL HERRIKO UNIBERTSITATEA;ADMINISTRACIÓN GENERAL DE LA COMUNIDAD AUTÓNOMA DE EUSKADI;HOSPITAL CLINIC;UNIVERSIDAD COMPLUTENSE DE MADRID;UNIVERSITAT DE BARCELONA;UNIVERSIDAD DE CÁDIZ;UNIVERSIDAD DE OVIEDO;UNIVERSIDAD DE ZARAGOZA;
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申请/专利号WO2016ES70473

发明设计人 MARTÍNEZ CENGOTITABENGOA MÓNICA;GONZÁLEZ-PINTO ANA MARÍA;ALBERICH MESA SUSANA;LEZA CERRO JUAN CARLOS;MACDOWELL MATA KARINA;PARELLADA REDONDO MARÍA JOSÉ;RODRÍGUEZ JIMÉNEZ ROBERTO;BERNARDO ARROYO MIGUEL;SÁIZ MARTÍNEZ PILAR ALEJANDRA;MICÓ SEGURA JUAN ANTONIO;LOBO SATUÉ ANTONIO;MATUTE ALMAU CARLOS;
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申请日2016-06-23

分类号G01N33/536;G01N33/68;

国家 WO

入库时间 2022-08-21 13:33:19

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机译：第一次精神病发作患者的体外预后或预测抗精神病药物治疗反应的方法和试剂盒

4. In vitro method and kit for the prognosis or prediction of response to treatment with antipsychotic agents by patients who have suffered a first psychotic episode (Machine-translation by Google Translate, not legally binding) [P] . ES2598248A2 . 2017-01-26

机译：用于首次精神病发作的患者预后或预测抗精神病药物治疗反应的体外方法和试剂盒（由Google Translate进行机器翻译，不具有法律约束力）

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机译：第一次精神病发作患者的体外预后或预测抗精神病药物治疗反应的方法和试剂盒

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3. Early response to antipsychotic therapy as a clinical marker of subsequent response in the treatment of patients with first-episode psychosis. [J] . Stauffer VL, Case M, Kinon BJ, Psychiatry research . 2011,第1a2期

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5. Prediction of acute clinical response following a first episode of non affective psychosis: Results of a cohort of 375 patients from the Spanish PAFIP study [J] . Crespo-FacorroB., delaFozV.O.G., Ayesa-ArriolaR., Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal . 2013,第Null期

6. Abnormal interhemispheric functional interactions in drug-naïve adult-onset first episode psychosis patients [C] . Danni Wang, Kaiming Zhuo, Yongjun Zhu, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

7. Machine Learning Methods for Diagnosis, Prognosis and Prediction of Long-term Treatment Outcome of Major Depression. [D] . Nie, Zhi. 2017

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