METHOD FOR PREPARING MODIFIED SODIUM ALGINATE EMBOLIZATION MICROSPHERE

摘要

A method for preparing a modified sodium alginate embolization microsphere and a method for loading an anti-cancer drug Adriamycin by the modified sodium alginate embolization microsphere, the preparation method comprising the following steps: (1) modifying sodium alginate with taurine to synthesize into modified sodium alginate; and (2) preparing a modified sodium alginate embolization microsphere by using a reverse phase emulsification method with high-concentration modified sodium alginate aqueous solution as the aqueous phase, mineral oil as the oil phase and polyaldehyde cellulose as the crosslinking agent. On the one hand, after modifying sodium alginate with taurine, a sulfonic acid group is introduced into an embolization microsphere, thus improving the loading rate of the drug. On the other hand, the viscosity of the sodium alginate solution is decreased, which is beneficial to the preparation of high-concentration sodium alginate solution, such that a regular sodium alginate embolization microsphere may be acquired.