P53-MDM2 - 11'25'--32'--25'- COMPOUNDS COMPRISING 11'25'-TETRAHYDROSPIROINDOLE-32'-PYRROLE-25'-DIONE SYSTEM AS INHIBITORS P53-MDM2 PROTEIN-PROTEIN INTERACTION

摘要

Wherein all symbols are as defined herein, with a spirooxoindole compound represented by the formula selected from the group consisting of formula (IA) and formula (IB) The compounds may find use in methods of preventing and / or treating diseases selected from the group consisting of cancer, immunological diseases, inflammatory conditions, allergic skin diseases associated with excessive proliferation, and viral infections.