2.5 PM2.5 Specific biomarker for identification of exposure to particulate matter 2.5PM2.5 and the method of identification using thereof

摘要

The present invention relates to a biomarker having a specific increase or decrease in gene expression due to particulate matter 2.5 (PM 2.5) of 2.5 micrometer (㎛) or less and the specific exposure of microscopic dust less than 2.5 micrometer using the same. Specifically, lung tissue samples were collected from mouse models exposed to two types of PM2.5 (water-soluble or organic) having different actual characteristics, and 2.5 μg of mouse gene-positive oligo microarray As a result of analyzing the gene expression changes of the samples by the gene expression profile of submicrometer fine dusts, it was confirmed that 25 genes whose expression was commonly changed by PM2.5 exposure were used to identify these genes as biomarkers, It can be used to monitor and determine PM2.5 contamination, Can be used as a tool for predicting the mechanism of action.