Specific biomarker for identification of exposure to volatile organic compounds and the method of identification using thereof

摘要

The present invention in a typical chemical VOCs (Volatile organic compounds, VOCs) specific for verifying whether human exposure to enemy biomarkers and it relates to a method determine whether the exposure to volatile organic compound using the same, more particularly, to volatile organic compounds, toluene (toluene) or determine whether xylene for (xylene) specific depending on whether alone or in combination of exposure to enemy alone exposure or multiple exposure to the biomarker, and toluene or xylene, using the same gene expression is increased or decreased It relates to a method. Exposure Status check method of the volatile organic compounds specific for verifying whether human exposure to volatile organic compounds in the inventive biomarkers and using the same will, through a DNA microarray using the reacted genes are identified as biomarkers specifically the VOCs typically it is possible to monitor whether single exposure or multiple exposure of toluene or xylene at an early stage, it can be useful to determine the human risk. In addition, it can also be usefully used as a tool to investigate the toxicity mechanism of action caused by the toluene and / or xylene.