PEPTIDES OBTAINED FROM p16^INK4a FOR PREVENTION AND TREATMENT OF HPV-ASSOCIATED TUMOURS AND OTHER TUMOURS EXPRESSING p16^INK4a

摘要

FIELD: biotechnology.;SUBSTANCE: invention is a fragment of a cyclin-dependent p16^INK4a kinase inhibitor, capable of inducing an immune response againstp16^INK4a, a nucleic acid molecule, a vector containing a nucleic acid molecule, a viral vector, as well as their use.;EFFECT: invention allows to increase secretion of interferon-gamma T-cells or induce T-cell proliferation, and use these fragments to immunize an individual against HPV-associated or other types of cancer expressing pl6^INK4a,preferably for the advanced types of cancer.;15 cl, 5 dwg, 1 tbl, 5 ex