METHOD FOR DISCOVERING PHARMACOLOGICALLY ACTIVE SUBSTANCE OF NATURAL PRODUCTS USING HIGH RESOLUTION MASS SPECTROMETRY AND PHARMACOLOGICAL ACTIVITY TEST

摘要

The invention discloses a kind of methods from natural products to find pharmacological active substance at a high speed comprising: the active multiple samples of active pharmacology are obtained by test; The sample of mass spectral analysis of the earthwork skiagraph based on generation is obtained by mass spectrometric methods; And determine the molecular weight of pharmacological active substance, by comparing and analyze it is described activity and above-mentioned earthwork skiagraph. Disclosed method allow quickly discovery pharmacological active substance carry out high resolution mass spec, multiple components, including with natural extracts sample, and with active testing data. The active of pharmacological active substance about intensity natural products allows to effectively utilize natural products.